What is Teneligliptin?

Teneligliptin is an oral drug used for the management of type 2 diabetes mellitus. It belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. This medication helps reduce blood sugar levels, particularly after meals.

How it works?

Teneligliptin works by inhibiting the DPP-4 enzyme. This enzyme is responsible for the breakdown of two important gut hormones called incretins: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By blocking the action of DPP-4, teneligliptin elevates the levels of incretins in the blood, incretins then stimulates liver to release more insulin. Teneligliptin also suppresses the release of glucagon, a hormone that raises blood sugar levels by signaling the liver to produce more glucose. The dual action of release of insulin and reducing glucagon production leads to better control of blood sugar levels.

Use :

Treatment of type 2 diabetes mellitus in adults.

Dosage :

The standard dose of teneligliptin is 20 mg taken once daily. The dose can be increased to 40 mg once daily if blood sugar levels are not adequately controlled. It can be taken empty stomach or with food.

Safety Precautions :

• Pregnancy and Breastfeeding: The safety of teneligliptin during pregnancy and breastfeeding has not been fully established. Consult your doctor before taking this medication.
• Kidney: Safe to use in kidney disease. Dose adjustments are not usually necessary for mild disease.
• Liver: Safe to use in liver disease. Dose adjustments are not usually necessary for mild disease.
• Pancreatitis: There have been rare reports of acute pancreatitis associated with DPP-4 inhibitors. If you develop severe and persistent abdominal pain, stop taking teneligliptin and contact your doctor immediately.
• Hypoglycemia: Be aware of the symptoms of low blood sugar like tremors, sweating, headache, dizziness. Your doctor will adjust the dose of anti-diabetic medications to reduce this risk.

Quick Points to Remember :

• Always take teneligliptin exactly as prescribed by your doctor.
• Regularly monitor your blood sugar levels to check the effectiveness of the medicine.
• Teneligliptin is most effective when combined with a healthy diet and exercise.
• Take your medicine at the same time each day and do not miss doses.
• Inform your doctor about any other medical conditions you have, like kidney or liver problems, and any other herbal medicines you are taking.

Side Effects :

• Hypoglycemia (low blood sugar)
• Nausea
• Itching or rash
• Common cold
• Sore throat
• Acute pancreatitis(rare)

Interactions with Other Drugs :

1. Sulfonylureas(glimepiride) and Insulin: Co-administration with these drugs significantly increases the risk of hypoglycemia. A lower dose of the sulfonylurea or insulin may be required.
2. Beta-blockers (eg.propranolol): These medications can mask the symptoms of hypoglycemia, making it harder to recognize leading to emergency situation.
3. Thiazide and other diuretics: These can increase blood sugar levels and may reduce the effectiveness of teneligliptin.
4. Corticosteroids: These can also increase blood glucose levels, potentially counteracting the effect of teneligliptin.
5. Ketoconazole and other CYP3A4 enzyme inhibitors: These may increase the levels of teneligliptin in the blood, potentially increasing the risk of side effects.

📦 Storage :

• Store at room temperature (68-77°F or 20-25°C)
• Keep in original container, tightly closed
• Protect from moisture and light